diff --git a/src/battle_util.c b/src/battle_util.c
index 54cc6a239b..e0146c265f 100644
--- a/src/battle_util.c
+++ b/src/battle_util.c
@@ -7976,6 +7976,18 @@ u8 ItemBattleEffects(u8 caseID, u32 battler, bool32 moveTurn)
             case HOLD_EFFECT_MARANGA_BERRY:  // consume and boost sp. defense if used special move
                 effect = DamagedStatBoostBerryEffect(battler, STAT_SPDEF, DAMAGE_CATEGORY_SPECIAL);
                 break;
+            case HOLD_EFFECT_CURE_STATUS: // only Toxic Chain's interaction with Knock Off
+            case HOLD_EFFECT_CURE_PSN:
+                if (gBattleMons[battler].status1 & STATUS1_PSN_ANY && !UnnerveOn(battler, gLastUsedItem) && gLastUsedAbility == ABILITY_TOXIC_CHAIN && gMovesInfo[gCurrentMove].effect == EFFECT_KNOCK_OFF)
+                {
+                    gBattleScripting.battler = battler;
+                    gBattleMons[battler].status1 &= ~(STATUS1_PSN_ANY | STATUS1_TOXIC_COUNTER);
+                    BattleScriptExecute(BattleScript_BerryCurePsnEnd2);
+                    BtlController_EmitSetMonData(battler, 0, REQUEST_STATUS_BATTLE, 0, 4, &gBattleMons[battler].status1);
+                    MarkBattlerForControllerExec(battler);
+                    effect = ITEM_STATUS_CHANGE;
+                }
+                break;
             case HOLD_EFFECT_STICKY_BARB:
                 if (TARGET_TURN_DAMAGED
                   && (!(gMoveResultFlags & MOVE_RESULT_NO_EFFECT))
diff --git a/test/battle/ability/toxic_chain.c b/test/battle/ability/toxic_chain.c
index 17ee455992..d6aba06f70 100644
--- a/test/battle/ability/toxic_chain.c
+++ b/test/battle/ability/toxic_chain.c
@@ -77,4 +77,36 @@ DOUBLE_BATTLE_TEST("Toxic Chain can inflict bad poison on both foes")
     }
 }
 
-TO_DO_BATTLE_TEST("Toxic Chain makes Lum/Pecha Berry trigger before being knocked off");
+SINGLE_BATTLE_TEST("Toxic Chain makes Lum/Pecha Berry trigger before being knocked off")
+{
+    u16 item = 0;
+
+    PARAMETRIZE { item = ITEM_PECHA_BERRY; }
+    PARAMETRIZE { item = ITEM_LUM_BERRY; }
+
+    GIVEN {
+        ASSUME(gMovesInfo[MOVE_KNOCK_OFF].category != DAMAGE_CATEGORY_STATUS);
+        ASSUME(gMovesInfo[MOVE_KNOCK_OFF].effect == EFFECT_KNOCK_OFF);
+        ASSUME(gMovesInfo[MOVE_KNOCK_OFF].power > 0);
+        ASSUME(gItemsInfo[ITEM_PECHA_BERRY].holdEffect == HOLD_EFFECT_CURE_PSN);
+        ASSUME(gItemsInfo[ITEM_LUM_BERRY].holdEffect == HOLD_EFFECT_CURE_STATUS);
+        PLAYER(SPECIES_OKIDOGI) { Ability(ABILITY_TOXIC_CHAIN); }
+        OPPONENT(SPECIES_WOBBUFFET) { Item(item); }
+    } WHEN {
+        TURN { MOVE(player, MOVE_KNOCK_OFF, WITH_RNG(RNG_TOXIC_CHAIN, TRUE)); }
+    } SCENE {
+        ABILITY_POPUP(player, ABILITY_TOXIC_CHAIN);
+        ANIMATION(ANIM_TYPE_STATUS, B_ANIM_STATUS_PSN, opponent);
+        MESSAGE("Foe Wobbuffet is badly poisoned!");
+        STATUS_ICON(opponent, badPoison: TRUE);
+        ANIMATION(ANIM_TYPE_GENERAL, B_ANIM_HELD_ITEM_EFFECT, opponent);
+        STATUS_ICON(opponent, badPoison: FALSE);
+        NONE_OF {
+            ANIMATION(ANIM_TYPE_GENERAL, B_ANIM_ITEM_KNOCKOFF);
+            MESSAGE("Okidogi knocked off Foe Wobbuffet's Pecha Berry!");
+            MESSAGE("Okidogi knocked off Foe Wobbuffet's Lum Berry!");
+        }
+    } THEN {
+        EXPECT(opponent->status1 == 0);
+    }
+}