diff --git a/include/config/overworld.h b/include/config/overworld.h
index 7831858d27..f62588b5fd 100644
--- a/include/config/overworld.h
+++ b/include/config/overworld.h
@@ -4,6 +4,9 @@
 // Movement config
 #define OW_RUNNING_INDOORS          GEN_LATEST  // In Gen4+, players are allowed to run indoors.
 
+// Other settings
+#define OW_POISON_DAMAGE            GEN_LATEST // In Gen4, Pokémon no longer faint from Poison in the overworld. In Gen5+, they no longer take damage at all.
+
 // Overworld flags
 // To use the following features in scripting, replace the 0s with the flag ID you're assigning it to.
 // Eg: Replace with FLAG_UNUSED_0x264 so you can use that flag to toggle the feature.
diff --git a/src/field_control_avatar.c b/src/field_control_avatar.c
index 96e9173c9b..b784a2ab86 100644
--- a/src/field_control_avatar.c
+++ b/src/field_control_avatar.c
@@ -565,11 +565,13 @@ static bool8 TryStartStepCountScript(u16 metatileBehavior)
 
     if (!(gPlayerAvatar.flags & PLAYER_AVATAR_FLAG_FORCED_MOVE) && !MetatileBehavior_IsForcedMovementTile(metatileBehavior))
     {
+    #if OW_POISON_DAMAGE < GEN_5
         if (UpdatePoisonStepCounter() == TRUE)
         {
             ScriptContext_SetupScript(EventScript_FieldPoison);
             return TRUE;
         }
+    #endif
         if (ShouldEggHatch())
         {
             IncrementGameStat(GAME_STAT_HATCHED_EGGS);
diff --git a/src/field_poison.c b/src/field_poison.c
index f254a6d142..da162e4134 100644
--- a/src/field_poison.c
+++ b/src/field_poison.c
@@ -44,7 +44,9 @@ static void FaintFromFieldPoison(u8 partyIdx)
     struct Pokemon *pokemon = &gPlayerParty[partyIdx];
     u32 status = STATUS1_NONE;
 
+#if OW_POISON_DAMAGE < GEN_4
     AdjustFriendship(pokemon, FRIENDSHIP_EVENT_FAINT_FIELD_PSN);
+#endif
     SetMonData(pokemon, MON_DATA_STATUS, &status);
     GetMonData(pokemon, MON_DATA_NICKNAME, gStringVar1);
     StringGet_Nickname(gStringVar1);
@@ -53,7 +55,11 @@ static void FaintFromFieldPoison(u8 partyIdx)
 static bool32 MonFaintedFromPoison(u8 partyIdx)
 {
     struct Pokemon *pokemon = &gPlayerParty[partyIdx];
+#if OW_POISON_DAMAGE < GEN_4
     if (IsMonValidSpecies(pokemon) && GetMonData(pokemon, MON_DATA_HP) == 0 && GetAilmentFromStatus(GetMonData(pokemon, MON_DATA_STATUS)) == AILMENT_PSN)
+#else
+    if (IsMonValidSpecies(pokemon) && GetMonData(pokemon, MON_DATA_HP) == 1 && GetAilmentFromStatus(GetMonData(pokemon, MON_DATA_STATUS)) == AILMENT_PSN)
+#endif
         return TRUE;
 
     return FALSE;
@@ -127,7 +133,11 @@ s32 DoPoisonFieldEffect(void)
         {
             // Apply poison damage
             hp = GetMonData(pokemon, MON_DATA_HP);
+        #if OW_POISON_DAMAGE < GEN_4
             if (hp == 0 || --hp == 0)
+        #else
+            if (hp == 1 || --hp == 1)
+        #endif
                 numFainted++;
 
             SetMonData(pokemon, MON_DATA_HP, &hp);
diff --git a/src/strings.c b/src/strings.c
index 8815212e05..847b2849a6 100644
--- a/src/strings.c
+++ b/src/strings.c
@@ -1191,7 +1191,11 @@ const u8 gText_PsychUp48BP[] = _("PSYCH UP{CLEAR_TO 0x4E}48BP");
 const u8 gText_IcePunch48BP[] = _("ICE PUNCH{CLEAR_TO 0x4E}48BP");
 const u8 gText_ThunderPunch48BP[] = _("THUNDERPUNCH{CLEAR_TO 0x4E}48BP");
 const u8 gText_FirePunch48BP[] = _("FIRE PUNCH{CLEAR_TO 0x4E}48BP");
+#if OW_POISON_DAMAGE < GEN_4
 const u8 gText_PkmnFainted_FldPsn[] = _("{STR_VAR_1} fainted…\p\n");
+#else
+const u8 gText_PkmnFainted_FldPsn[] = _("{STR_VAR_1} survived the poisoning.\nThe poison faded away!\p");
+#endif
 const u8 gText_Marco[] = _("MARCO");
 const u8 gText_TrainerCardName[] = _("NAME: ");
 const u8 gText_TrainerCardIDNo[] = _("IDNo.");